4K24

Structure of anti-uPAR Fab ATN-658 in complex with uPAR

Summary for 4K24

• Entry DOI: 10.2210/pdb4k24/pdb
• Related: 4K23
• Descriptor: Urokinase-type plasminogen activator, Vitronectin, anti-uPAR antibody, heavy chain, ... (8 entities in total)
• Functional Keywords: immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 101423.45

Authors

Huang, M.D.,Xu, X.,Yuan, C. (deposition date: 2013-04-08, release date: 2014-02-26, Last modification date: 2023-11-08)

• Primary citation: Xu, X.,Cai, Y.,Wei, Y.,Donate, F.,Juarez, J.,Parry, G.,Chen, L.,Meehan, E.J.,Ahn, R.W.,Ugolkov, A.,Dubrovskyi, O.,O'halloran, T.V.,Huang, M.,Mazar, A.P.; Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M); Plos One, 9:e85349-e85349, 2014; PubMed: 24465541; DOI: 10.1371/journal.pone.0085349

Experimental method

X-RAY DIFFRACTION (4.5 Å)