4JZU

Crystal structure of the Bacillus subtilis pyrophosphohydrolase BsRppH bound to a non-hydrolysable triphosphorylated dinucleotide RNA (pcp-pGpG) - first guanosine residue in guanosine binding pocket

4JZU の概要

• エントリーDOI: 10.2210/pdb4jzu/pdb
• 関連するPDBエントリー: 4JZS 4JZT 4JZV
• 分子名称: RNA PYROPHOSPHOHYDROLASE, RNA (5'-R(*(GCP)P*G)-3'), 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: nudix hydrolase, rna pyrophosphohydrolase, rpph, cytosol, hydrolase, hydrolase-rna complex, hydrolase/rna
• 由来する生物種: Bacillus subtilis subsp. subtilis
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 38122.23

構造登録者

Piton, J.,Larue, V.,Thillier, Y.,Dorleans, A.,Pellegrini, O.,Li de la Sierra-Gallay, I.,Vasseur, J.J.,Debart, F.,Tisne, C.,Condon, C. (登録日: 2013-04-03, 公開日: 2013-05-08, 最終更新日: 2024-04-03)

• 主引用文献: Piton, J.,Larue, V.,Thillier, Y.,Dorleans, A.,Pellegrini, O.,Li de la Sierra-Gallay, I.,Vasseur, J.J.,Debart, F.,Tisne, C.,Condon, C.; Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates.; Proc.Natl.Acad.Sci.USA, 110:8858-8863, 2013; PubMed: 23610407; DOI: 10.1073/pnas.1221510110

実験手法

X-RAY DIFFRACTION (1.7 Å)