Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors

Summary for 4JZR

DescriptorEgl nine homolog 1, NICKEL (II) ION, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, ... (5 entities in total)
Functional Keywordsprolyl hydroxylase, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q9GZT9
Total number of polymer chains1
Total molecular weight24751.79
Ma, Y.,Yang, L. (deposition date: 2013-04-03, release date: 2013-10-30)
Primary citation
Deng, G.,Zhao, B.,Ma, Y.,Xu, Q.,Wang, H.,Yang, L.,Zhang, Q.,Guo, T.B.,Zhang, W.,Jiao, Y.,Cai, X.,Zhang, J.,Liu, H.,Guan, X.,Lu, H.,Xiang, J.,Elliott, J.D.,Lin, X.,Ren, F.
Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors
Bioorg.Med.Chem., 21:6349-6358, 2013
PubMed: 24055079 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmc.2013.08.046
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.256600.6%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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