4JZR

Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors

4JZR の概要

• エントリーDOI: 10.2210/pdb4jzr/pdb
• 分子名称: Egl nine homolog 1, NICKEL (II) ION, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, ... (5 entities in total)
• 機能のキーワード: prolyl hydroxylase, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9GZT9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24751.79

構造登録者

Ma, Y.,Yang, L. (登録日: 2013-04-03, 公開日: 2013-10-30)

• 主引用文献: Deng, G.,Zhao, B.,Ma, Y.,Xu, Q.,Wang, H.,Yang, L.,Zhang, Q.,Guo, T.B.,Zhang, W.,Jiao, Y.,Cai, X.,Zhang, J.,Liu, H.,Guan, X.,Lu, H.,Xiang, J.,Elliott, J.D.,Lin, X.,Ren, F.; Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors; Bioorg.Med.Chem., 21:6349-6358, 2013; PubMed: 24055079; DOI: 10.1016/j.bmc.2013.08.046

実験手法

X-RAY DIFFRACTION (2.1 Å)