4JZN

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1

4JZN の概要

• エントリーDOI: 10.2210/pdb4jzn/pdb
• 関連するPDBエントリー: 4JZO
• 分子名称: Anti-HCV E2 Fab HC84-1 heavy chain, Anti-HCV E2 Fab HC84-1 light chain, Envelope glycoprotein E2, ... (5 entities in total)
• 機能のキーワード: fab fragment, immunglobulin fold, antibody, immune system, viral protein-immune system complex, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 153871.18

構造登録者

Krey, T.,Rey, F.A. (登録日: 2013-04-03, 公開日: 2013-06-05, 最終更新日: 2023-09-20)

• 主引用文献: Krey, T.,Meola, A.,Keck, Z.Y.,Damier-Piolle, L.,Foung, S.K.,Rey, F.A.; Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.; Plos Pathog., 9:e1003364-e1003364, 2013; PubMed: 23696737; DOI: 10.1371/journal.ppat.1003364

実験手法

X-RAY DIFFRACTION (2.05 Å)