4JZN
Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1
4JZN の概要
エントリーDOI | 10.2210/pdb4jzn/pdb |
関連するPDBエントリー | 4JZO |
分子名称 | Anti-HCV E2 Fab HC84-1 heavy chain, Anti-HCV E2 Fab HC84-1 light chain, Envelope glycoprotein E2, ... (5 entities in total) |
機能のキーワード | fab fragment, immunglobulin fold, antibody, immune system, viral protein-immune system complex, immune system-viral protein complex, immune system/viral protein |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958 |
タンパク質・核酸の鎖数 | 7 |
化学式量合計 | 153871.18 |
構造登録者 | |
主引用文献 | Krey, T.,Meola, A.,Keck, Z.Y.,Damier-Piolle, L.,Foung, S.K.,Rey, F.A. Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape. Plos Pathog., 9:e1003364-e1003364, 2013 Cited by PubMed: 23696737DOI: 10.1371/journal.ppat.1003364 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.05 Å) |
構造検証レポート
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