4JZB

Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with 1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-3-PHENYLPYRIDINIUM, IPP and Ca2+

Summary for 4JZB

Entry DOI	10.2210/pdb4jzb/pdb
Descriptor	Farnesyl pyrophosphate synthase, CALCIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	geranyl transferase, fpps, farnesyl pyrophosphate synthase, farnesyl diphosphate synthase, cytosolic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Leishmania major
Total number of polymer chains	2
Total formula weight	83589.47
Authors	Aripirala, S.,Amzel, L.M.,Gabelli, S. (deposition date: 2013-04-02, release date: 2014-02-12, Last modification date: 2017-11-15)
Primary citation	Aripirala, S.,Gonzalez-Pacanowska, D.,Oldfield, E.,Kaiser, M.,Amzel, L.M.,Gabelli, S.B. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. Acta Crystallogr.,Sect.D, 70:802-810, 2014 Cited by PubMed: 24598749 DOI: 10.1107/S1399004713033221 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation