4JZB

Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with 1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-3-PHENYLPYRIDINIUM, IPP and Ca2+

4JZB の概要

• エントリーDOI: 10.2210/pdb4jzb/pdb
• 分子名称: Farnesyl pyrophosphate synthase, CALCIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: geranyl transferase, fpps, farnesyl pyrophosphate synthase, farnesyl diphosphate synthase, cytosolic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83589.47

構造登録者

Aripirala, S.,Amzel, L.M.,Gabelli, S. (登録日: 2013-04-02, 公開日: 2014-02-12, 最終更新日: 2017-11-15)

• 主引用文献: Aripirala, S.,Gonzalez-Pacanowska, D.,Oldfield, E.,Kaiser, M.,Amzel, L.M.,Gabelli, S.B.; Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.; Acta Crystallogr.,Sect.D, 70:802-810, 2014; PubMed: 24598749; DOI: 10.1107/S1399004713033221

実験手法

X-RAY DIFFRACTION (1.9 Å)