4JYW

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057

Summary for 4JYW

• Entry DOI: 10.2210/pdb4jyw/pdb
• Related: 4JZ0
• Descriptor: Glutamate carboxypeptidase 2, N-{6-[(4-fluorobenzoyl)amino]hexanoyl}-L-gamma-glutamyl-5-{[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]oxy}-L-norvaline, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: hydrolase, metallopeptidase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
• Total number of polymer chains: 1
• Total formula weight: 84131.11

Authors

Barinka, C. (deposition date: 2013-04-01, release date: 2014-04-02, Last modification date: 2020-07-29)

• Primary citation: Ganguly, T.,Dannoon, S.,Geruntho, J.G.,Hopkins, M.R.,Murphy, S.,Cahaya, H.,Blecha, J.E.,Jivan, S.,Barinka, C.,Jones, E.F.,VanBrocklin, H.F.,Berkman, C.E.; A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer; To be Published,

Experimental method

X-RAY DIFFRACTION (1.73 Å)