4JYW

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057

4JYW の概要

• エントリーDOI: 10.2210/pdb4jyw/pdb
• 関連するPDBエントリー: 4JZ0
• 分子名称: Glutamate carboxypeptidase 2, N-{6-[(4-fluorobenzoyl)amino]hexanoyl}-L-gamma-glutamyl-5-{[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]oxy}-L-norvaline, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: hydrolase, metallopeptidase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 84131.11

構造登録者

Barinka, C. (登録日: 2013-04-01, 公開日: 2014-04-02, 最終更新日: 2020-07-29)

• 主引用文献: Ganguly, T.,Dannoon, S.,Geruntho, J.G.,Hopkins, M.R.,Murphy, S.,Cahaya, H.,Blecha, J.E.,Jivan, S.,Barinka, C.,Jones, E.F.,VanBrocklin, H.F.,Berkman, C.E.; A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer; To be Published,

実験手法

X-RAY DIFFRACTION (1.73 Å)