4JVL

Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and estradiol (E2)

Summary for 4JVL

• Entry DOI: 10.2210/pdb4jvl/pdb
• Related: 1G3M 4JVM 4JVN
• Descriptor: Estrogen sulfotransferase, ADENOSINE-3'-5'-DIPHOSPHATE, ESTRADIOL, ... (6 entities in total)
• Functional Keywords: cytosolic sulfotransferase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P49888
• Total number of polymer chains: 2
• Total formula weight: 72129.13

Authors

Gosavi, R.A.,Knudsen, G.A.,Birnbaum, L.S.,Pedersen, L.C. (deposition date: 2013-03-25, release date: 2013-09-04, Last modification date: 2023-09-20)

Primary citation

Gosavi, R.A.,Knudsen, G.A.,Birnbaum, L.S.,Pedersen, L.C.
Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis.
Environ.Health Perspect., 121:1194-1199, 2013

PubMed Abstract: Brominated flame retardants (BFRs), used in many types of consumer goods, are being studied because of concerns about possible health effects related to endocrine disruption, immunotoxicity, reproductive toxicity, and neurotoxicity. Tetrabromobisphenol A (TBBPA), the most widely used BFR, and human metabolites of certain congeners of polybrominated diphenyl ether (e.g., 3-OH-BDE-47) have been suggested to inhibit estrogen sulfotransferase, potentially affecting estrogen metabolism.

PubMed: 23959441
DOI: 10.1289/ehp.1306902

Experimental method

X-RAY DIFFRACTION (1.943 Å)