4JVG

B-Raf Kinase in Complex with Birb796

Summary for 4JVG

Entry DOI	10.2210/pdb4jvg/pdb
Descriptor	Serine/threonine-protein kinase B-raf, 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA (2 entities in total)
Functional Keywords	kinase, phosphotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P15056
Total number of polymer chains	4
Total formula weight	131110.39
Authors	Lavoie, H.,Thevakumaran, N.,Gavory, G.,Li, J.,Padeganeh, A.,Guiral, S.,Duchaine, J.,Mao, D.Y.L.,Bouvier, M.,Sicheri, F.,Therrien, M. (deposition date: 2013-03-25, release date: 2013-05-29, Last modification date: 2024-02-28)
Primary citation	Lavoie, H.,Thevakumaran, N.,Gavory, G.,Li, J.J.,Padeganeh, A.,Guiral, S.,Duchaine, J.,Mao, D.Y.,Bouvier, M.,Sicheri, F.,Therrien, M. Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat.Chem.Biol., 9:428-436, 2013 Cited by PubMed: 23685672 DOI: 10.1038/nchembio.1257 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.09 Å)

Structure validation