4JVE
Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
Summary for 4JVE
Entry DOI | 10.2210/pdb4jve/pdb |
Related | 4JV7 4JV9 4JVR 4JWR |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid (3 entities in total) |
Functional Keywords | p53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 1 |
Total formula weight | 11684.45 |
Authors | Huang, X.,Gonzalez-Lopez de Turiso, F.,Sun, D.,Yosup, R.,Bartberger, M.D.,Beck, H.P.,Cannon, J.,Shaffer, P.,Oliner, J.D.,Olson, S.H.,Medina, J.C. (deposition date: 2013-03-25, release date: 2013-05-01, Last modification date: 2013-06-05) |
Primary citation | Gonzalez-Lopez de Turiso, F.,Sun, D.,Rew, Y.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Correll, T.L.,Huang, X.,Julian, L.D.,Kayser, F.,Lo, M.C.,Long, A.M.,McMinn, D.,Oliner, J.D.,Osgood, T.,Powers, J.P.,Saiki, A.Y.,Schneider, S.,Shaffer, P.,Xiao, S.H.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H. Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors. J.Med.Chem., 56:4053-4070, 2013 Cited by PubMed: 23597064DOI: 10.1021/jm400293z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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