4JVB
Crystal structure of PDE6D in complex with the inhibitor rac-2
Summary for 4JVB
Entry DOI | 10.2210/pdb4jvb/pdb |
Related | 4JV6 4JV8 4JVF |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole (3 entities in total) |
Functional Keywords | immunoglobulin-like beta-sandwich, gdi-like solubilizing factor, prenyl binding, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18145.81 |
Authors | Gunther, Z.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.,Triola, G.,Wittinghofer, A.,Bastiaens, P.,Waldmann, H. (deposition date: 2013-03-25, release date: 2013-05-22, Last modification date: 2023-09-20) |
Primary citation | Zimmermann, G.,Papke, B.,Ismail, S.,Vartak, N.,Chandra, A.,Hoffmann, M.,Hahn, S.A.,Triola, G.,Wittinghofer, A.,Bastiaens, P.I.,Waldmann, H. Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling Nature, 497:638-642, 2013 Cited by PubMed: 23698361DOI: 10.1038/nature12205 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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