4JVA

Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog

4JVA の概要

• エントリーDOI: 10.2210/pdb4jva/pdb
• 関連するPDBエントリー: 1CX4 4JV4
• 分子名称: cAMP-dependent protein kinase type II-beta regulatory subunit, (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide (3 entities in total)
• 機能のキーワード: camp-dependent protein kinase, cyclic nucleotide analogs, isoform selectivity, fluorescence anisotropy, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cytoplasm (By similarity): P12369
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34984.45

構造登録者

Brown, S.H.J.,Cheng, C.Y.,Saldanha, A.S.,Wu, J.,Cottam, H.,Sankaran, B.,Taylor, S.S. (登録日: 2013-03-25, 公開日: 2013-09-18, 最終更新日: 2023-09-20)

• 主引用文献: Brown, S.H.,Cheng, C.Y.,Saldanha, S.A.,Wu, J.,Cottam, H.B.,Sankaran, B.,Taylor, S.S.; Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs.; Acs Chem.Biol., 8:2164-2172, 2013; PubMed: 23978166; DOI: 10.1021/cb400247t

実験手法

X-RAY DIFFRACTION (2.5 Å)