4JUP

Dimeric structure of CARMA1 CARD

4JUP の概要

• エントリーDOI: 10.2210/pdb4jup/pdb
• 分子名称: Caspase recruitment domain-containing protein 11 (2 entities in total)
• 機能のキーワード: protein interaction, protein binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q9BXL7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24806.39

構造登録者

Park, H.H. (登録日: 2013-03-25, 公開日: 2014-02-05, 最終更新日: 2024-10-16)

主引用文献

Jang, T.H.,Park, J.H.,Park, H.H.
Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD
Plos One, 8:e79778-e79778, 2013

PubMed Abstract: CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important role of the CARMA1 signalosome during lymphocyte activation and proliferation, limited structural information is available. Here, we report the dimeric structure of CARMA1 CARD at a resolution of 3.2 Å. Interestingly, although CARMA1 CARD has a canonical six helical-bundles structural fold similar to other CARDs, CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism.

PubMed: 24224005
DOI: 10.1371/journal.pone.0079778

実験手法

X-RAY DIFFRACTION (3.2 Å)