4JT5

mTORdeltaN-mLST8-pp242 complex

Summary for 4JT5

Entry DOI	10.2210/pdb4jt5/pdb
Descriptor	Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol (3 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345 Cytoplasm (By similarity): Q9BVC4
Total number of polymer chains	4
Total formula weight	341737.36
Authors	Pavletich, N.P.,Yang, H. (deposition date: 2013-03-22, release date: 2013-05-08, Last modification date: 2024-02-28)
Primary citation	Yang, H.,Rudge, D.G.,Koos, J.D.,Vaidialingam, B.,Yang, H.J.,Pavletich, N.P. mTOR kinase structure, mechanism and regulation. Nature, 497:217-223, 2013 Cited by PubMed: 23636326 DOI: 10.1038/nature12122 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.45 Å)

Structure validation