4JT0
Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4a
Summary for 4JT0
Entry DOI | 10.2210/pdb4jt0/pdb |
Related | 1JD2 4JSQ 4JSU |
Related PRD ID | PRD_001045 PRD_001049 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total) |
Functional Keywords | ups, proteasome, drug discovery, non-covalent reversible inhibition, bivalence, tmc-95a derivatives, ntn hydrolase, non-lysosomal protein breakdown, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 30 |
Total formula weight | 730715.54 |
Authors | Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M. (deposition date: 2013-03-22, release date: 2013-05-01, Last modification date: 2023-11-15) |
Primary citation | Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M. Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome. J.Med.Chem., 56:3367-3378, 2013 Cited by PubMed: 23540790DOI: 10.1021/jm4002007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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