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4JT0

Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4a

Summary for 4JT0
Entry DOI10.2210/pdb4jt0/pdb
Related1JD2 4JSQ 4JSU
Related PRD IDPRD_001045 PRD_001049
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
Functional Keywordsups, proteasome, drug discovery, non-covalent reversible inhibition, bivalence, tmc-95a derivatives, ntn hydrolase, non-lysosomal protein breakdown, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (yeast)
More
Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains30
Total formula weight730715.54
Authors
Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M. (deposition date: 2013-03-22, release date: 2013-05-01, Last modification date: 2023-11-15)
Primary citationDesvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M.
Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome.
J.Med.Chem., 56:3367-3378, 2013
Cited by
PubMed: 23540790
DOI: 10.1021/jm4002007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

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数据于2024-04-17公开中

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