4JT0

Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4a

4JT0 の概要

• エントリーDOI: 10.2210/pdb4jt0/pdb
• 関連するPDBエントリー: 1JD2 4JSQ 4JSU
• 関連するBIRD辞書のPRD_ID: PRD_001045 PRD_001049
• 分子名称: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
• 機能のキーワード: ups, proteasome, drug discovery, non-covalent reversible inhibition, bivalence, tmc-95a derivatives, ntn hydrolase, non-lysosomal protein breakdown, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 30
• 化学式量合計: 730715.54

構造登録者

Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M. (登録日: 2013-03-22, 公開日: 2013-05-01, 最終更新日: 2023-11-15)

• 主引用文献: Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M.; Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome.; J.Med.Chem., 56:3367-3378, 2013; PubMed: 23540790; DOI: 10.1021/jm4002007

実験手法

X-RAY DIFFRACTION (3.1 Å)