4JSX

structure of mTORDeltaN-mLST8-Torin2 complex

Summary for 4JSX

Entry DOI	10.2210/pdb4jsx/pdb
Descriptor	Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one (3 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (human) More
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345 Cytoplasm (By similarity): Q9BVC4
Total number of polymer chains	4
Total formula weight	341985.47
Authors	Pavletich, N.P.,Yang, H. (deposition date: 2013-03-22, release date: 2013-05-08, Last modification date: 2024-02-28)
Primary citation	Yang, H.,Rudge, D.G.,Koos, J.D.,Vaidialingam, B.,Yang, H.J.,Pavletich, N.P. mTOR kinase structure, mechanism and regulation. Nature, 497:217-223, 2013 Cited by PubMed: 23636326 DOI: 10.1038/nature12122 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation