4JSQ

Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4e

Summary for 4JSQ

• Entry DOI: 10.2210/pdb4jsq/pdb
• Related: 1JD2 1RYP 4JSU 4JT0
• Related PRD ID: PRD_001041
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total)
• Functional Keywords: ups, proteasome, drug discovery, non-covalent reversible inhibition, bivalence, tmc-95a derivatives, ntn hydrolase, non-lysosomal protein breakdown, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 30
• Total formula weight: 731135.18

Authors

Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M. (deposition date: 2013-03-22, release date: 2013-05-01, Last modification date: 2023-11-15)

• Primary citation: Desvergne, A.,Genin, E.,Marechal, X.,Gallastegui, N.,Dufau, L.,Richy, N.,Groll, M.,Vidal, J.,Reboud-Ravaux, M.; Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome; J.Med.Chem., 56:3367-3378, 2013; PubMed: 23540790; DOI: 10.1021/jm4002007

Experimental method

X-RAY DIFFRACTION (2.8 Å)