4JSF

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)

4JSF の概要

• エントリーDOI: 10.2210/pdb4jsf/pdb
• 関連するPDBエントリー: 4JSE 4JSG 4JSH 4JSI 4JSJ 4JSK 4JSL 4JSM
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100148.92

構造登録者

Li, H.,Poulos, T.L. (登録日: 2013-03-22, 公開日: 2013-08-07, 最終更新日: 2023-09-20)

• 主引用文献: Jing, Q.,Li, H.,Fang, J.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.; Bioorg.Med.Chem., 21:5323-5331, 2013; PubMed: 23867386; DOI: 10.1016/j.bmc.2013.06.014

実験手法

X-RAY DIFFRACTION (2.05 Å)