4JS6
Crystal structure of inhibitor-free hCAII H94D
Summary for 4JS6
| Entry DOI | 10.2210/pdb4js6/pdb |
| Related | 4JSA 4JSS 4JSW 4JSZ |
| Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ... (4 entities in total) |
| Functional Keywords | lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29653.11 |
| Authors | Martin, D.P.,Hann, Z.S.,Cohen, S.M. (deposition date: 2013-03-22, release date: 2013-06-19, Last modification date: 2023-09-20) |
| Primary citation | Martin, D.P.,Hann, Z.S.,Cohen, S.M. Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site. Inorg.Chem., 52:12207-12215, 2013 Cited by PubMed Abstract: An ever-increasing number of metalloproteins are being discovered that play essential roles in physiological processes. Inhibitors of these proteins have significant potential for the treatment of human disease, but clinical success of these compounds has been limited. Herein, zinc(II)-dependent metalloprotein inhibitors in clinical use are reviewed, and the potential for using novel metal-binding groups (MBGs) in the design of these inhibitors is discussed. By using human carbonic anhydrase II as a model system, the nuances of MBG-metal interactions in the context of a protein environment can be probed. Understanding how metal coordination influences inhibitor binding may help in the design of new therapeutics targeting metalloproteins. PubMed: 23706138DOI: 10.1021/ic400295f PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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