4JQL

Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid

Summary for 4JQL

Entry DOI	10.2210/pdb4jql/pdb
Descriptor	Heat shock protein HSP 90-alpha, valerjesomycin, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	inhibitor design, hsp90, nucleotide binding domain, chaperone, geldanamycin, cytosole, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	28547.28
Authors	Jeso, V.,Iqbal, S.,Hernandez, P.,Cameron, M.D.,Park, H.,Lograsso, P.V.,Micalizio, G.C. (deposition date: 2013-03-20, release date: 2013-04-10, Last modification date: 2024-02-28)
Primary citation	Jeso, V.,Iqbal, S.,Hernandez, P.,Cameron, M.D.,Park, H.,Lograsso, P.V.,Micalizio, G.C. Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic Acid. Angew.Chem.Int.Ed.Engl., 52:4800-4804, 2013 Cited by PubMed: 23554224 DOI: 10.1002/anie.201301323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation