4JPM

Structure of SHV-1 beta-lactamase in complex with the 7-alkylidenecephalosporin DCM-1-10 at 1.14 Ang resolution

Summary for 4JPM

Entry DOI	10.2210/pdb4jpm/pdb
Related	4FH4
Descriptor	Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, 7-alkylidenecephalosporin DCM-1-10, bound form, ... (5 entities in total)
Functional Keywords	class a beta-lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	32918.90
Authors	Rodkey, E.A.,van den Akker, F. (deposition date: 2013-03-19, release date: 2013-12-04, Last modification date: 2023-09-20)
Primary citation	Rodkey, E.A.,McLeod, D.C.,Bethel, C.R.,Smith, K.M.,Xu, Y.,Chai, W.,Che, T.,Carey, P.R.,Bonomo, R.A.,van den Akker, F.,Buynak, J.D. beta-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme. J.Am.Chem.Soc., 135:18358-18369, 2013 Cited by PubMed: 24219313 DOI: 10.1021/ja403598g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.14 Å)

Structure validation