4JMU

Crystal structure of HIV matrix residues 1-111 in complex with inhibitor

4JMU の概要

• エントリーDOI: 10.2210/pdb4jmu/pdb
• 分子名称: Gag-Pol polyprotein, SULFATE ION, 5-{4-[(4-methoxybenzoyl)amino]phenoxy}-2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}benzoic acid, ... (4 entities in total)
• 機能のキーワード: structural protein matrix, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13408.28

構造登録者

Lemke, C.T. (登録日: 2013-03-14, 公開日: 2013-10-30, 最終更新日: 2024-02-28)

• 主引用文献: Laplante, S.R.,Forgione, P.,Boucher, C.,Coulombe, R.,Gillard, J.,Hucke, O.,Jakalian, A.,Joly, M.A.,Kukolj, G.,Lemke, C.,McCollum, R.,Titolo, S.,Beaulieu, P.L.,Stammers, T.; Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity.; J.Med.Chem., 57:1944-1951, 2014; PubMed: 24024973; DOI: 10.1021/jm401202a

実験手法

X-RAY DIFFRACTION (2 Å)