4JM2

Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab

Summary for 4JM2

• Entry DOI: 10.2210/pdb4jm2/pdb
• Related: 4JM4
• Descriptor: PGT 135 Heavy chain, TETRAETHYLENE GLYCOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: immunoglobulin fold, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 158950.50

Authors

Kong, L.,Wilson, I.A. (deposition date: 2013-03-13, release date: 2013-05-29, Last modification date: 2020-07-29)

• Primary citation: Kong, L.,Lee, J.H.,Doores, K.J.,Murin, C.D.,Julien, J.P.,McBride, R.,Liu, Y.,Marozsan, A.,Cupo, A.,Klasse, P.J.,Hoffenberg, S.,Caulfield, M.,King, C.R.,Hua, Y.,Le, K.M.,Khayat, R.,Deller, M.C.,Clayton, T.,Tien, H.,Feizi, T.,Sanders, R.W.,Paulson, J.C.,Moore, J.P.,Stanfield, R.L.,Burton, D.R.,Ward, A.B.,Wilson, I.A.; Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.; Nat.Struct.Mol.Biol., 20:796-803, 2013; PubMed: 23708606; DOI: 10.1038/nsmb.2594

Experimental method

X-RAY DIFFRACTION (3.1 Å)