4JL4
Crystal structure of the complex between PPARgamma LBD and the ligand LJ570 [(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid]
Summary for 4JL4
Entry DOI | 10.2210/pdb4jl4/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid (3 entities in total) |
Functional Keywords | bundle of alpha-helices, small four-strnded beta-sheet, transcription factor, rxr, transcription-agonist complex, transcription/agonist |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65782.11 |
Authors | Pochetti, G.,Montanari, R.,Capelli, D. (deposition date: 2013-03-12, release date: 2014-03-12, Last modification date: 2024-05-22) |
Primary citation | Laghezza, A.,Piemontese, L.,Cerchia, C.,Montanari, R.,Capelli, D.,Giudici, M.,Crestani, M.,Tortorella, P.,Peiretti, F.,Pochetti, G.,Lavecchia, A.,Loiodice, F. Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation. J.Med.Chem., 61:8282-8298, 2018 Cited by PubMed: 30199253DOI: 10.1021/acs.jmedchem.8b00835 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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