4JL4

Crystal structure of the complex between PPARgamma LBD and the ligand LJ570 [(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid]

4JL4 の概要

• エントリーDOI: 10.2210/pdb4jl4/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid (3 entities in total)
• 機能のキーワード: bundle of alpha-helices, small four-strnded beta-sheet, transcription factor, rxr, transcription-agonist complex, transcription/agonist
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65782.11

構造登録者

Pochetti, G.,Montanari, R.,Capelli, D. (登録日: 2013-03-12, 公開日: 2014-03-12, 最終更新日: 2023-08-02)

• 主引用文献: Laghezza, A.,Piemontese, L.,Cerchia, C.,Montanari, R.,Capelli, D.,Giudici, M.,Crestani, M.,Tortorella, P.,Peiretti, F.,Pochetti, G.,Lavecchia, A.,Loiodice, F.; Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation.; J.Med.Chem., 61:8282-8298, 2018; PubMed: 30199253; DOI: 10.1021/acs.jmedchem.8b00835

実験手法

X-RAY DIFFRACTION (2.5 Å)