4JIY

RNA three-way junction stabilized by a supramolecular di-iron(II) cylinder drug

Summary for 4JIY

• Entry DOI: 10.2210/pdb4jiy/pdb
• Related: 2ET0 3FX8 3I1D
• Descriptor: 5'-(CGUACG)-3', N-[(1E)-PYRIDIN-2-YLMETHYLENE]-N-[4-(4-{[(1E)-PYRIDIN-2-YLMETHYLENE]AMINO}BENZYL)PHENYL]AMINE, FE (II) ION, ... (4 entities in total)
• Functional Keywords: rna, three-way junction, drug-rna complex, rna structure recognition, cylinder, supramolecule
• Total number of polymer chains: 1
• Total formula weight: 2867.48

Authors

Sigel, R.K.O.,Schnabl, J.A.,Freisinger, E.,Spingler, B.,Hannon, M.J. (deposition date: 2013-03-07, release date: 2013-09-04, Last modification date: 2024-02-28)

Primary citation

Phongtongpasuk, S.,Paulus, S.,Schnabl, J.,Sigel, R.K.,Spingler, B.,Hannon, M.J.,Freisinger, E.
Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction.
Angew.Chem.Int.Ed.Engl., 52:11513-11516, 2013

PubMed Abstract: Getting to the heart of it: Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.

PubMed: 24039102
DOI: 10.1002/anie.201305079

Experimental method

X-RAY DIFFRACTION (1.91 Å)