4JIT
Crystal Structure of E. coli XGPRT in complex with (S)-3-(Guanin-9-yl)pyrrolidin-N-ylacetylphosphonic acid
Summary for 4JIT
Entry DOI | 10.2210/pdb4jit/pdb |
Related | 4JLS |
Descriptor | Xanthine phosphoribosyltransferase, {2-[(3S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pyrrolidin-1-yl]-2-oxoethyl}phosphonic acid (3 entities in total) |
Functional Keywords | xanthine-guanine phosphoribosyltransferase, purine salvage, nucleoside phosphonate, antibacterial, transferase |
Biological source | Escherichia coli |
Cellular location | Cell membrane ; Peripheral membrane protein : H0Q6L9 |
Total number of polymer chains | 4 |
Total formula weight | 68650.77 |
Authors | Keough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.J.,de Jersey, J.,Guddat, L.W. (deposition date: 2013-03-07, release date: 2014-12-24, Last modification date: 2024-02-28) |
Primary citation | Keough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.,de Jersey, J.,Guddat, L.W. Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. J.Med.Chem., 56:6967-6984, 2013 Cited by PubMed: 23927482DOI: 10.1021/jm400779n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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