4JFW

Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(propylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol

4JFW の概要

• エントリーDOI: 10.2210/pdb4jfw/pdb
• 関連するPDBエントリー: 2WVV 4J27 4J28 4JFS 4JFT 4JFU 4JFV
• 分子名称: alpha-L-fucosidase, (3alpha)-[3-({2-[(2S,3S,4R,5S)-3,4-dihydroxy-5-methylpyrrolidin-2-yl]ethyl}amino)propyl]ferrocene, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: alpha-l-fucosidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bacteroides thetaiotaomicron
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 210817.74

構造登録者

Wright, D.W.,Davies, G.J. (登録日: 2013-02-28, 公開日: 2013-09-18, 最終更新日: 2023-09-20)

• 主引用文献: Hottin, A.,Wright, D.W.,Steenackers, A.,Delannoy, P.,Dubar, F.,Biot, C.,Davies, G.J.,Behr, J.B.; alpha-L-fucosidase inhibition by pyrrolidine-ferrocene hybrids: rationalization of ligand-binding properties by structural studies.; Chemistry, 19:9526-9533, 2013; PubMed: 23740878; DOI: 10.1002/chem.201301001

実験手法

X-RAY DIFFRACTION (2.1 Å)