4JBO
Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
Summary for 4JBO
Entry DOI | 10.2210/pdb4jbo/pdb |
Related | 3K5U 3M11 4JBP 4JBQ |
Descriptor | Aurora kinase A, 1-(4-{2-[(6-{4-[2-(dimethylamino)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea (3 entities in total) |
Functional Keywords | aurora kinase inhibitors, hurp, mitotic spindle, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 32895.75 |
Authors | Wu, J.S.,Leou, J.S.,Peng, Y.H.,Hsueh, C.C.,Hsieh, H.P.,Wu, S.Y. (deposition date: 2013-02-20, release date: 2013-06-05, Last modification date: 2024-03-20) |
Primary citation | Wu, J.M.,Chen, C.T.,Coumar, M.S.,Lin, W.H.,Chen, Z.J.,Hsu, J.T.,Peng, Y.H.,Shiao, H.Y.,Lin, W.H.,Chu, C.Y.,Wu, J.S.,Lin, C.T.,Chen, C.P.,Hsueh, C.C.,Chang, K.Y.,Kao, L.P.,Huang, C.Y.,Chao, Y.S.,Wu, S.Y.,Hsieh, H.P.,Chi, Y.H. Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc.Natl.Acad.Sci.USA, 110:E1779-E1787, 2013 Cited by PubMed: 23610398DOI: 10.1073/pnas.1220523110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.493 Å) |
Structure validation
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