4JAP

Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

4JAP の概要

• エントリーDOI: 10.2210/pdb4jap/pdb
• 関連するPDBエントリー: 4JAO 4JAQ 4JAR 4JAT 4JD3
• 分子名称: Alpha-pyrone synthesis polyketide synthase-like Pks11, PALMITIC ACID, COENZYME A, ... (5 entities in total)
• 機能のキーワード: lipid biosynthesis, structural genomics, enzyme function initiative, ketosynthase enzyme, alkylpyrone synthesis, transferase, mycobacterium tuberculosis structural proteomics project, xmtb
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 153397.47

構造登録者

Gokulan, K.,Sacchettini, J.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (登録日: 2013-02-19, 公開日: 2013-04-24, 最終更新日: 2013-11-27)

• 主引用文献: Gokulan, K.,O'Leary, S.E.,Russell, W.K.,Russell, D.H.,Lalgondar, M.,Begley, T.P.,Ioerger, T.R.,Sacchettini, J.C.; Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.; J.Biol.Chem., 288:16484-16494, 2013; PubMed: 23615910; DOI: 10.1074/jbc.M113.468892

実験手法

X-RAY DIFFRACTION (1.833 Å)