4JA8
Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with AGI-6780 Inhibitor
Summary for 4JA8
Entry DOI | 10.2210/pdb4ja8/pdb |
Descriptor | Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-yl-phenyl]-3-[3-(trifluoromethyl)phenyl]urea, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complex, metabolic enzyme oncometabolite, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion: P48735 |
Total number of polymer chains | 2 |
Total formula weight | 96688.35 |
Authors | Wei, W.,Chen, L.,Wu, M.,Jiang, F.,Travins, J.,Qian, K.,DeLaBarre, B. (deposition date: 2013-02-18, release date: 2013-04-10, Last modification date: 2024-02-28) |
Primary citation | Wang, F.,Travins, J.,DeLaBarre, B.,Penard-Lacronique, V.,Schalm, S.,Hansen, E.,Straley, K.,Kernytsky, A.,Liu, W.,Gliser, C.,Yang, H.,Gross, S.,Artin, E.,Saada, V.,Mylonas, E.,Quivoron, C.,Popovici-Muller, J.,Saunders, J.O.,Salituro, F.G.,Yan, S.,Murray, S.,Wei, W.,Gao, Y.,Dang, L.,Dorsch, M.,Agresta, S.,Schenkein, D.P.,Biller, S.A.,Su, S.M.,de Botton, S.,Yen, K.E. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science, 340:622-626, 2013 Cited by PubMed: 23558173DOI: 10.1126/science.1234769 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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