4J93

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BI-1

Summary for 4J93

• Entry DOI: 10.2210/pdb4j93/pdb
• Related: 4E91 4E92
• Descriptor: Gag protein, 4-{2-[5-(3-chlorophenyl)-1H-pyrazol-4-yl]-1-[3-(1H-imidazol-1-yl)propyl]-1H-benzimidazol-5-yl}benzoic acid, (4S)-3-phenyl-4-(pyridin-3-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one, ... (4 entities in total)
• Functional Keywords: structural protein capsid, viral protein, viral protein-viral protein inhibitor complex, viral protein/viral protein inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (By similarity). Virion (By similarity): Q79791
• Total number of polymer chains: 1
• Total formula weight: 17003.85

Authors

Lemke, C.T. (deposition date: 2013-02-15, release date: 2013-07-10, Last modification date: 2024-02-28)

• Primary citation: Lamorte, L.,Titolo, S.,Lemke, C.T.,Goudreau, N.,Mercier, J.F.,Wardrop, E.,Shah, V.B.,von Schwedler, U.K.,Langelier, C.,Banik, S.S.,Aiken, C.,Sundquist, W.I.,Mason, S.W.; Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes.; Antimicrob.Agents Chemother., 57:4622-4631, 2013; PubMed: 23817385; DOI: 10.1128/AAC.00985-13

Experimental method

X-RAY DIFFRACTION (1.74 Å)