4J93

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BI-1

4J93 の概要

• エントリーDOI: 10.2210/pdb4j93/pdb
• 関連するPDBエントリー: 4E91 4E92
• 分子名称: Gag protein, 4-{2-[5-(3-chlorophenyl)-1H-pyrazol-4-yl]-1-[3-(1H-imidazol-1-yl)propyl]-1H-benzimidazol-5-yl}benzoic acid, (4S)-3-phenyl-4-(pyridin-3-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one, ... (4 entities in total)
• 機能のキーワード: structural protein capsid, viral protein, viral protein-viral protein inhibitor complex, viral protein/viral protein inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (By similarity). Virion (By similarity): Q79791
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17003.85

構造登録者

Lemke, C.T. (登録日: 2013-02-15, 公開日: 2013-07-10, 最終更新日: 2024-02-28)

• 主引用文献: Lamorte, L.,Titolo, S.,Lemke, C.T.,Goudreau, N.,Mercier, J.F.,Wardrop, E.,Shah, V.B.,von Schwedler, U.K.,Langelier, C.,Banik, S.S.,Aiken, C.,Sundquist, W.I.,Mason, S.W.; Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes.; Antimicrob.Agents Chemother., 57:4622-4631, 2013; PubMed: 23817385; DOI: 10.1128/AAC.00985-13

実験手法

X-RAY DIFFRACTION (1.74 Å)