4J6R
Crystal structure of broadly and potently neutralizing antibody VRC23 in complex with HIV-1 gp120
Summary for 4J6R
| Entry DOI | 10.2210/pdb4j6r/pdb |
| Related | 3SE8 3SE9 3U7Y 4JB9 |
| Descriptor | Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY VRC23, LIGHT CHAIN OF ANTIBODY VRC23, ... (10 entities in total) |
| Functional Keywords | hiv, gp120, cd4-binding site, vrc23, neutralization, vaccine, antibody, envelope protein, immune system, viral protein-immune system complex, viral protein/immune system |
| Biological source | HUMAN IMMUNODEFICIENCY VIRUS 1 More |
| Total number of polymer chains | 3 |
| Total formula weight | 90604.45 |
| Authors | Zhou, T.,Moquin, S.,Kwong, P.D. (deposition date: 2013-02-11, release date: 2013-05-08, Last modification date: 2024-10-16) |
| Primary citation | Georgiev, I.S.,Doria-Rose, N.A.,Zhou, T.,Kwon, Y.D.,Staupe, R.P.,Moquin, S.,Chuang, G.Y.,Louder, M.K.,Schmidt, S.D.,Altae-Tran, H.R.,Bailer, R.T.,McKee, K.,Nason, M.,O'Dell, S.,Ofek, G.,Pancera, M.,Srivatsan, S.,Shapiro, L.,Connors, M.,Migueles, S.A.,Morris, L.,Nishimura, Y.,Martin, M.A.,Mascola, J.R.,Kwong, P.D. Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science, 340:751-756, 2013 Cited by PubMed Abstract: Serum characterization and antibody isolation are transforming our understanding of the humoral immune response to viral infection. Here, we show that epitope specificities of HIV-1-neutralizing antibodies in serum can be elucidated from the serum pattern of neutralization against a diverse panel of HIV-1 isolates. We determined "neutralization fingerprints" for 30 neutralizing antibodies on a panel of 34 diverse HIV-1 strains and showed that similarity in neutralization fingerprint correlated with similarity in epitope. We used these fingerprints to delineate specificities of polyclonal sera from 24 HIV-1-infected donors and a chimeric siman-human immunodeficiency virus-infected macaque. Delineated specificities matched published specificities and were further confirmed by antibody isolation for two sera. Patterns of virus-isolate neutralization can thus afford a detailed epitope-specific understanding of neutralizing-antibody responses to viral infection. PubMed: 23661761DOI: 10.1126/science.1233989 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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