4J6R

Crystal structure of broadly and potently neutralizing antibody VRC23 in complex with HIV-1 gp120

4J6R の概要

• エントリーDOI: 10.2210/pdb4j6r/pdb
• 関連するPDBエントリー: 3SE8 3SE9 3U7Y 4JB9
• 分子名称: Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY VRC23, LIGHT CHAIN OF ANTIBODY VRC23, ... (10 entities in total)
• 機能のキーワード: hiv, gp120, cd4-binding site, vrc23, neutralization, vaccine, antibody, envelope protein, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: HUMAN IMMUNODEFICIENCY VIRUS 1; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 90604.45

構造登録者

Zhou, T.,Moquin, S.,Kwong, P.D. (登録日: 2013-02-11, 公開日: 2013-05-08, 最終更新日: 2023-09-20)

• 主引用文献: Georgiev, I.S.,Doria-Rose, N.A.,Zhou, T.,Kwon, Y.D.,Staupe, R.P.,Moquin, S.,Chuang, G.Y.,Louder, M.K.,Schmidt, S.D.,Altae-Tran, H.R.,Bailer, R.T.,McKee, K.,Nason, M.,O'Dell, S.,Ofek, G.,Pancera, M.,Srivatsan, S.,Shapiro, L.,Connors, M.,Migueles, S.A.,Morris, L.,Nishimura, Y.,Martin, M.A.,Mascola, J.R.,Kwong, P.D.; Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.; Science, 340:751-756, 2013; PubMed: 23661761; DOI: 10.1126/science.1233989

実験手法

X-RAY DIFFRACTION (1.64 Å)