4J5T

Crystal structure of Processing alpha-Glucosidase I

Summary for 4J5T

Entry DOI	10.2210/pdb4j5t/pdb
Descriptor	Mannosyl-oligosaccharide glucosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	super-beta sandwich linked to (alpha/alpha)6 toroid, glycoside hydrolase, glycosylation, er membrane, n-glycoprotein, hydrolase
Biological source	Saccharomyces cerevisiae (yeast)
Cellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein: P53008
Total number of polymer chains	1
Total formula weight	95132.44
Authors	Barker, M.K.,Rose, D.R. (deposition date: 2013-02-09, release date: 2013-04-03, Last modification date: 2024-11-20)
Primary citation	Barker, M.K.,Rose, D.R. Specificity of processing alpha-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies. J.Biol.Chem., 288:13563-13574, 2013 Cited by PubMed Abstract: The enzyme “GluI” is key to the synthesis of critical glycoproteins in the cell. PubMed: 23536181 DOI: 10.1074/jbc.M113.460436 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation