4J4N

Crystal structure of FK506 binding domain of plasmodium falciparum FKBP35 in complex with D44

4J4N の概要

• エントリーDOI: 10.2210/pdb4j4n/pdb
• 関連するPDBエントリー: 2OFN 2VN1 4J4O
• 分子名称: FK506-binding protein (FKBP)-type peptidyl-propyl isomerase, N-(2-ethylphenyl)-2-(3H-imidazo[4,5-b]pyridin-2-ylsulfanyl)acetamide (3 entities in total)
• 機能のキーワード: d44, fkbp35, fk506 binding, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44531.43

構造登録者

Sreekanth, R.,Harikishore, A.,Yoon, H.S. (登録日: 2013-02-07, 公開日: 2013-09-11, 最終更新日: 2024-10-09)

主引用文献

Harikishore, A.,Niang, M.,Rajan, S.,Preiser, P.R.,Yoon, H.S.
Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent.
Sci Rep, 3:2501-2501, 2013

PubMed Abstract: Malaria parasite strains have emerged to tolerate the therapeutic effects of the prophylactics and drugs presently available. This resistance now poses a serious challenge to researchers in the bid to overcome malaria parasitic infection. Recent studies have shown that FK520 and its analogs inhibit malaria parasites growth by binding to FK506 binding proteins (FKBPs) of the parasites. Structure based drug screening efforts based on three-dimensional structural information of FKBPs from Plasmodium falciparum led us to identify new chemical entities that bind to the parasite FKBP35 and inhibit its growth. Our experimental results verify that this novel compound (D44) modulate the PPIase activity of Plasmodium FKBP35 and demonstrate the stage-specific growth inhibition of Plasmodium falciparum strains. Here, we present the X-ray crystallographic structures of FK506 binding domains (FKBDs) of PfFKBP35 and PvFKBP35 in complex with the newly identified inhibitor providing molecular insights into its mode of action.

PubMed: 23974147
DOI: 10.1038/srep02501

実験手法

X-RAY DIFFRACTION (2.75 Å)