4J3N

Human Topoisomerase Iibeta in complex with DNA

Summary for 4J3N

• Entry DOI: 10.2210/pdb4j3n/pdb
• Related: 3QX3 4G0U 4G0V 4G0W
• Descriptor: DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (5 entities in total)
• Functional Keywords: toprim domain, winged-helix domain, coiled-coil domain, dna binding and cleavage, nucleus, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q02880
• Total number of polymer chains: 6
• Total formula weight: 196208.86

Authors

Wu, C.C.,Li, T.K.,Li, Y.C.,Chan, N.L. (deposition date: 2013-02-06, release date: 2013-10-02, Last modification date: 2023-11-08)

• Primary citation: Wu, C.C.,Li, Y.C.,Wang, Y.R.,Li, T.K.,Chan, N.L.; On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs; Nucleic Acids Res., 41:10630-10640, 2013; PubMed: 24038465; DOI: 10.1093/nar/gkt828

Experimental method

X-RAY DIFFRACTION (2.3 Å)