4J3I

X-ray crystal structure of bromodomain complex to 1.24 A resolution

Summary for 4J3I

Entry DOI	10.2210/pdb4j3i/pdb
Descriptor	Bromodomain-containing protein 4, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	brd4, bromodomain, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15616.90
Authors	Stein, A.J.,White, A.,Suto, R.K. (deposition date: 2013-02-05, release date: 2014-01-15, Last modification date: 2023-09-20)
Primary citation	McLure, K.G.,Gesner, E.M.,Tsujikawa, L.,Kharenko, O.A.,Attwell, S.,Campeau, E.,Wasiak, S.,Stein, A.,White, A.,Fontano, E.,Suto, R.K.,Wong, N.C.,Wagner, G.S.,Hansen, H.C.,Young, P.R. RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One, 8:e83190-e83190, 2013 Cited by PubMed: 24391744 DOI: 10.1371/journal.pone.0083190 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.24 Å)

Structure validation