4J2T
Inhibitor-bound Ca2+ ATPase
Summary for 4J2T
Entry DOI | 10.2210/pdb4j2t/pdb |
Related | 2C8K 3N5K 3NAL 3NAM 3NAN |
Descriptor | SERCA1a, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3a,4-bis(butanoyloxy)-3-hydroxy-3,6,9-trimethyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, PHOSPHATIDYLETHANOLAMINE, ... (5 entities in total) |
Functional Keywords | p-type atpase, calcium transport, thapsigargin analog, sarco(endo)plasmic reticulum, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Oryctolagus cuniculus (rabbit) |
Cellular location | Membrane ; Multi-pass membrane protein : B6CAM1 |
Total number of polymer chains | 1 |
Total formula weight | 111096.56 |
Authors | Paulsen, E.S.,Villadsen, J.,Tenori, E.,Liu, H.,Lie, M.A.,Bonde, D.F.,Bublitz, M.,Olesen, C.,Autzen, H.E.,Dach, I.,Sehgal, P.,Moller, J.V.,Schiott, B.,Nissen, P.,Christensen, S.B. (deposition date: 2013-02-05, release date: 2013-06-19, Last modification date: 2023-09-20) |
Primary citation | Paulsen, E.S.,Villadsen, J.,Tenori, E.,Liu, H.,Bonde, D.F.,Lie, M.A.,Bublitz, M.,Olesen, C.,Autzen, H.E.,Dach, I.,Sehgal, P.,Nissen, P.,Moller, J.V.,Schiott, B.,Christensen, S.B. Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. J.Med.Chem., 56:3609-3619, 2013 Cited by PubMed: 23574308DOI: 10.1021/jm4001083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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