4J2T

Inhibitor-bound Ca2+ ATPase

Summary for 4J2T

Entry DOI	10.2210/pdb4j2t/pdb
Related	2C8K 3N5K 3NAL 3NAM 3NAN
Descriptor	SERCA1a, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3a,4-bis(butanoyloxy)-3-hydroxy-3,6,9-trimethyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, PHOSPHATIDYLETHANOLAMINE, ... (5 entities in total)
Functional Keywords	p-type atpase, calcium transport, thapsigargin analog, sarco(endo)plasmic reticulum, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Oryctolagus cuniculus (rabbit)
Cellular location	Membrane ; Multi-pass membrane protein : B6CAM1
Total number of polymer chains	1
Total formula weight	111096.56
Authors	Paulsen, E.S.,Villadsen, J.,Tenori, E.,Liu, H.,Lie, M.A.,Bonde, D.F.,Bublitz, M.,Olesen, C.,Autzen, H.E.,Dach, I.,Sehgal, P.,Moller, J.V.,Schiott, B.,Nissen, P.,Christensen, S.B. (deposition date: 2013-02-05, release date: 2013-06-19, Last modification date: 2023-09-20)
Primary citation	Paulsen, E.S.,Villadsen, J.,Tenori, E.,Liu, H.,Bonde, D.F.,Lie, M.A.,Bublitz, M.,Olesen, C.,Autzen, H.E.,Dach, I.,Sehgal, P.,Nissen, P.,Moller, J.V.,Schiott, B.,Christensen, S.B. Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. J.Med.Chem., 56:3609-3619, 2013 Cited by PubMed: 23574308 DOI: 10.1021/jm4001083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation