4J1A

X-ray structure of the adduct between hen egg white lysozyme and AziRu (green crystal)

4J1A の概要

• エントリーDOI: 10.2210/pdb4j1a/pdb
• 関連するPDBエントリー: 4J1B
• 分子名称: Lysozyme C, CHLORIDE ION, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: c-type lysozyme/alpha-lactalbumin family, hydrolase
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14561.58

構造登録者

Vergara, A.,Merlino, A. (登録日: 2013-02-01, 公開日: 2013-04-03, 最終更新日: 2024-11-20)

主引用文献

Vergara, A.,D'Errico, G.,Montesarchio, D.,Mangiapia, G.,Paduano, L.,Merlino, A.
Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu.
Inorg.Chem., 52:4157-4159, 2013

PubMed Abstract: The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu-protein adduct formation and of ligand exchange in the crystal state.

PubMed: 23517183
DOI: 10.1021/ic4004142

実験手法

X-RAY DIFFRACTION (1.79 Å)