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4J0S

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

Summary for 4J0S
Entry DOI10.2210/pdb4j0s/pdb
Related4J0R
DescriptorBromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(S)-hydroxy(phenyl)methyl]phenol, ... (4 entities in total)
Functional Keywordsbrd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, isoxazole, structural genomics consortium, sgc, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity): O60885
Total number of polymer chains1
Total formula weight15642.98
Authors
Primary citationHewings, D.S.,Fedorov, O.,Filippakopoulos, P.,Martin, S.,Picaud, S.,Tumber, A.,Wells, C.,Olcina, M.M.,Freeman, K.,Gill, A.,Ritchie, A.J.,Sheppard, D.W.,Russell, A.J.,Hammond, E.M.,Knapp, S.,Brennan, P.E.,Conway, S.J.
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
J.Med.Chem., 56:3217-3227, 2013
Cited by
PubMed: 23517011
DOI: 10.1021/jm301588r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.84 Å)
Structure validation

217705

건을2024-03-27부터공개중

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