4J0R
Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand
4J0R の概要
エントリーDOI | 10.2210/pdb4j0r/pdb |
関連するPDBエントリー | 4J0S |
分子名称 | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(R)-hydroxy(phenyl)methyl]phenol, ... (5 entities in total) |
機能のキーワード | brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, isoxazole, structural genomics consortium, sgc, signaling protein |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus (By similarity): O60885 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15769.89 |
構造登録者 | Filippakopoulos, P.,Picaud, S.,Qi, J.,Felletar, I.,Hewings, D.S.,von Delft, F.,Conway, S.J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2013-01-31, 公開日: 2013-02-13, 最終更新日: 2023-09-20) |
主引用文献 | Hewings, D.S.,Fedorov, O.,Filippakopoulos, P.,Martin, S.,Picaud, S.,Tumber, A.,Wells, C.,Olcina, M.M.,Freeman, K.,Gill, A.,Ritchie, A.J.,Sheppard, D.W.,Russell, A.J.,Hammond, E.M.,Knapp, S.,Brennan, P.E.,Conway, S.J. Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem., 56:3217-3227, 2013 Cited by PubMed: 23517011DOI: 10.1021/jm301588r 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.72 Å) |
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