4IZ0
Crystal structure of HCV NS5B polymerase in complex with 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
4IZ0 の概要
エントリーDOI | 10.2210/pdb4iz0/pdb |
関連するPDBエントリー | 3MWV 3MWW 4GMC |
分子名称 | RNA-directed RNA polymerase, 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide (3 entities in total) |
機能のキーワード | hcv ns5b, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Hepatitis C virus (HCV) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): O92972 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 129254.47 |
構造登録者 | |
主引用文献 | Stammers, T.A.,Coulombe, R.,Rancourt, J.,Thavonekham, B.,Fazal, G.,Goulet, S.,Jakalian, A.,Wernic, D.,Tsantrizos, Y.,Poupart, M.A.,Bos, M.,McKercher, G.,Thauvette, L.,Kukolj, G.,Beaulieu, P.L. Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23:2585-2589, 2013 Cited by PubMed: 23545108DOI: 10.1016/j.bmcl.2013.02.110 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.22 Å) |
構造検証レポート
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