4IXE

pcDHFR-NADPH-270

4IXE の概要

• エントリーDOI: 10.2210/pdb4ixe/pdb
• 関連するPDBエントリー: 2CD4 4IXF 4IXG
• 分子名称: Dihydrofolate reductase, N~6~-methyl-N~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: dihydrofolate reductase inhibitor cofactor ternary complex, reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24984.23

構造登録者

Cody, V. (登録日: 2013-01-25, 公開日: 2013-05-29, 最終更新日: 2023-09-20)

• 主引用文献: Gangjee, A.,Namjoshi, O.A.,Raghavan, S.,Queener, S.F.,Kisliuk, R.L.,Cody, V.; Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald-Hartwig Aminations of Heterocycles.; J.Med.Chem., 56:4422-4441, 2013; PubMed: 23627352; DOI: 10.1021/jm400086g

実験手法

X-RAY DIFFRACTION (1.54 Å)